P-329 Oocyte donation outcomes in endometriosis patients with multiple IVF failures

Abstract Study question What are the reproductive outcomes and prognostic factors of live birth rates in endometriosis patients referred to oocyte donation after multiple vitro fertilization(IVF)-failures? Summary answer In this specific population, appears be a viable option optimize outcomes, as cumulative rate reaches 63.2%. is known already Assisted Reproductive Technology(ART) currently recognized one main therapeutic options manage endometriosis-related infertility, often resulting satisfactory outcome. A burning issue field remains how deal with undergoing recurrent ART failures. As there appear two contributing failures, i.e., deleterious effect on embryo implantation altered quality, competing strategies can considered:(i) surgery (ii) donation. However, no data has been published date population previous IVF design, size, duration Observational cohort study including fifty-seven women infertility failures (≥ 2 failed cycles) who consulted at our institution between January 2013 June 2022. Participants/materials, setting, methods Endometriosis was diagnosed based imaging criteria using transvaginal sonography magnetic resonance confirmed histologically had history for endometriosis. The measured were clinical pregnancy (CPR) (CLBR). We compared characteristics versus those did not univariate multivariate analysis identify determinant fertility Main results role chance Fifty-seven underwent 90 cycles, 244 autologous cycles. mean age 36.8 ± 3.3 years, 3.6 2.2 number IVF/ICSI cycles 4.4 2.3 per patient. Three (5.3%) superficial endometriosis, (3.5%) ovarian endometriomas, 52 (91.2%) deep infiltrating among which 30 (57.7%) bowel lesions. Thirty (52.6%) associated adenomyosis. Overall, CPR CLBR patient 49/57 (85.9%) 36/57 (63.2%), respectively. After analysis, only being nulligravida (p = 0.002) remained an independent negative predictive factor rate. Limitations, reasons caution 35.1% surgical/histological proof all participants, staged interviews, examination, techniques assess phenotypes, line structured diagnostic process acknowledged appropriate Wider implications findings poor quality may limiting success rates, rather than impaired endometrial receptivity. These reason clinicians systematically refer infertile surgery. Trial registration applicable